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About HYMPAVZIAbout
HYMPAVZIOverviewHYMPAVZI in ActionEfficacyEfficacyStudy DesignPrimary EndpointsSecondary EndpointsSafetyDosing & AdminDosing 

& AdminDosingPen OverviewInjection OverviewPatient StoriesPatient
StoriesMeet a Real PatientIdentifying Potential PatientsResourcesResourcesResourcesPatient Savings & Support
Full Prescribing InformationPatient InformationInstructions for UseIndication Patient Site
HYMPAVZI inhibits tissue factor pathway inhibitor (TFPI)1See HYMPAVZI in action HYMPAVZI works within the extrinsic pathway of the coagulation cascade

HYMPAVZI targets TFPI, a natural anticoagulant and primary inhibitor of the
extrinsic coagulation cascade.1-3

 TFPI downregulates the extrinsic pathway

Through the Kunitz 2 (K2) domain, TFPI binds to and inhibits factor Xa (FXa). FXa, along with factor Va (FVa), is a key complex that catalyzes the conversion of prothrombin to thrombin.4,5

 HYMPAVZI inhibits TFPI via the K2 domain

HYMPAVZI targets and inhibits TFPI via the K2 domain, thus helping to prevent TFPI’s inhibition of FXa and leading to thrombin generation and clot formation.1,5

 This innovative anti-TFPI approach helps to achieve hemostasis regardless of factor VIII or factor IX deficiency1,3,6 Bleed protection delivered

In the BASIS Study, HYMPAVZI demonstrated reductions in ABR compared with on-demand factor-based treatment and routine factor-based prophylaxis treatment1*

 Learn more about the BASIS Study LoadingABR=annualized bleed rate.92% reduction in treated bleeds on HYMPAVZI compared to on-demand factor-based treatment (3.20 ABR vs 39.86 ABR). 36% reduction in treated bleeds on HYMPAVZI compared to routine factor-based prophylaxis treatment (5.09 ABR vs 7.90 ABR).1References:1. HYMPAVZI. Prescribing Information. Pfizer Inc.; 2025. 2. Mast AE, et al. J Thromb Haemost. 2022;20(6):1290-1300. 3. Pittman DD, et al. Res Pract Thromb Haemost. 2022;6(2):e12679. 4. Ellsworth P, et al. Hematology Am Soc Hematol Educ Program. 2021;2021(1):219-225. 5. Miyazawa K, et al. Biophys J. 2023;122(1):99-113. 6. Srivastava A, et al. Haemophilia. 2020;26(suppl 6):1-158.About HYMPAVZIConsistent protectionComparison of ABR of treated bleeds with HYMPAVZI vs on-demand factor-based treatment and vs routine factor-based prophylaxis treatment1 See efficacy data Loading

HYMPAVZI is a registered trademark of Pfizer Inc.

HYMPAVZI is a registered trademark of Pfizer Inc.

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PP-HYM-USA-0601
Indications and usageHYMPAVZI is indicated for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients 12 years of age and older with:
  • hemophilia A (congenital factor VIII deficiency) without factor VIII inhibitors, or
  • hemophilia B (congenital factor IX deficiency) without factor IX inhibitors.
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Important Safety InformationVenous thrombotic events were reported in clinical studies with HYMPAVZI. Patients with independent risk factors for thromboembolic events may be at increased risk of thromboembolic events with use of HYMPAVZI. Consider the benefit and risk of using HYMPAVZI in patients with known risk factors for thromboembolism. Interrupt HYMPAVZI prophylaxis if diagnostic findings consistent with thromboembolism occur and manage as clinically indicated. If factor VIII or factor IX products are indicated in a patient receiving HYMPAVZI prophylaxis, the minimum effective dose of factor VIII or factor IX according to the product label is recommended.

HYMPAVZI may cause hypersensitivity reactions (including, but not limited to, urticaria and pruritus). If HYMPAVZI-treated patients develop a severe hypersensitivity reaction, advise patients to discontinue HYMPAVZI and seek immediate emergency treatment.

Based on its mechanism of action, HYMPAVZI may cause fetal harm when administered to a pregnant woman. Verify that females of reproductive potential are not pregnant prior to initiating HYMPAVZI. Advise pregnant women of the potential risk to the fetus. Advise females of reproductive potential to use effective contraception during treatment with HYMPAVZI and for 2 months after the last dose.

A serious adverse reaction of peripheral swelling occurred in one patient. A serious adverse reaction of venous thrombosis occurred in 0.9% of patients (1/116) in the open-label extension study. Adverse reactions reported in ≥3% of patients treated with HYMPAVZI in clinical trials included injection site reaction (9% of patients); headache (7% of patients); pruritus (3% of patients).IndicationsHYMPAVZI is indicated for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients 12 years of age and older with:
  • hemophilia A (congenital factor VIII deficiency) without factor VIII inhibitors, or
  • hemophilia B (congenital factor IX deficiency) without factor IX inhibitors.