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About HYMPAVZIAbout
HYMPAVZIOverviewHYMPAVZI in ActionEfficacyEfficacyStudy DesignPrimary EndpointsSecondary EndpointsSafetyDosing & AdminDosing 

& AdminDosingPen OverviewInjection OverviewPatient ProfilesPatient
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Full Prescribing InformationPatient InformationInstructions for UseIndication Patient Site
HYMPAVZI is designed to help prevent or reduce bleeding episodes1-4HYMPAVZI is designed to help prevent or reduce bleeding episodes1-4

Innovative mechanism of action: anti-TFPI*

A human monoclonal antibody, HYMPAVZI is an anti-tissue factor pathway inhibitor (anti-TFPI) that may help achieve hemostasis in eligible patients with FVIII or FIX deficiency.1-4

Rebalancing vs replacing

HYMPAVZI helps to achieve hemostasis through rebalancing, which is a non-factor treatment approach that inhibits endogenous anticoagulants (eg, TFPI). This allows thrombin generation and enhances coagulation without replacing factor.1,5,6

Specific binding

HYMPAVZI targets and inhibits TFPI via the the K2 domain, thus helping to prevent TFPI’s inhibition of FXa and leading to thrombin generation and clot formation.1,7

Innovative mechanism of action: anti-TFPI*

A human monoclonal antibody, HYMPAVZI is an anti-tissue factor pathway inhibitor (anti-TFPI) that may help achieve hemostasis in eligible patients with FVIII or FIX deficiency.1-4

Rebalancing vs replacing

HYMPAVZI helps to achieve hemostasis through rebalancing, which is a non-factor treatment approach that inhibits endogenous anticoagulants (eg, TFPI). This allows thrombin generation and enhances coagulation without replacing factor.1,5,6

Specific binding

HYMPAVZI targets and inhibits TFPI via the the K2 domain, thus helping to prevent TFPI’s inhibition of FXa and leading to thrombin generation and clot formation.1,7

HYMPAVZI uses an innovative mechanism, targeting TFPI to help achieve hemostasis, offering your eligible patients an alternative treatment approach1,5,6,8-10

HYMPAVZI uses an innovative mechanism, targeting TFPI to help achieve
hemostasis, offering your eligible patients an alternative treatment
approach1,5,6,8-10

 See HYMPAVZI in action Loading See HYMPAVZI in action LoadingABR=annualized bleed rate; FIX=factor IX; FVIII=factor VIII; FXa=factor Xa; K2=Kunitz 2 domain.HYMPAVZI is a TFPI antagonist.1References:1. HYMPAVZI. Prescribing Information. Pfizer Inc.; 2024. 2. Butterfield JSS, et al. Mol Ther. 2020;28(3):997‑1015. 3. Srivastava A, et al. Haemophilia. 2020;26(suppl 6):1-158. 4. Pittman DD, et al. Res Pract Thromb Haemost. 2022;6(2):e12679. 5. Ozelo MC, et al. Res Pract Thromb Haemost. 2022;6(3):e12695. 6. Ellsworth P, et al. Hematology Am Soc Hematol Educ Program. 2021;2021(1):219-225. 7. Miyazawa K, et al. Biophys J. 2023;122(1):99-113. 8. Kizilocak H, et al. Clin Adv Hematol Oncol. 2019;17(6):344-351. 9. Chowdary P. Int J Hematol. 2020;111(1):42-50. 10. Mast AE, et al. J Thromb Haemost.
2022;20(6):1290-1300. About HYMPAVZI Bleed protection

Comparison of ABR of treated bleeds with HYMPAVZI vs on-demand factor-based treatment and routine factor-based prophylaxis treatment1

 See efficacy data Loading

HYMPAVZI is a trademark of Pfizer Inc.

To report an adverse event, please call 1-800-438-1985

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PP-HYM-USA-0073
Indications and usageHYMPAVZI is indicated for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients 12 years of age and older with:
 
  • hemophilia A (congenital factor VIII deficiency) without factor VIII inhibitors, or
  • hemophilia B (congenital factor IX deficiency) without factor IX inhibitors.
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Important Safety InformationHYMPAVZI is a tissue factor pathway inhibitor (TFPI) antagonist and may increase the risk of thromboembolic complications. Interrupt HYMPAVZI prophylaxis if diagnostic findings consistent with thromboembolism occur and manage as clinically indicated. If factor VIII or factor IX products are indicated in a patient receiving HYMPAVZI prophylaxis, the minimum effective dose of factor VIII or factor IX according to the product label is recommended.

HYMPAVZI may cause hypersensitivity reactions (including, but not limited to, urticaria and pruritus). If HYMPAVZI-treated patients develop a severe hypersensitivity reaction, advise patients to discontinue HYMPAVZI and seek immediate emergency treatment.

Based on its mechanism of action, HYMPAVZI may cause fetal harm when administered to a pregnant woman. Verify that females of reproductive potential are not pregnant prior to initiating HYMPAVZI. Advise pregnant women of the potential risk to the fetus. Advise females of reproductive potential to use effective contraception during treatment with HYMPAVZI and for 2 months after the last dose.

A serious adverse reaction of peripheral swelling occurred in one patient. Adverse reactions reported in ≥3% of patients treated with HYMPAVZI in clinical trials included injection site reaction (9% of patients); headache (7% of patients); pruritus (3% of patients).IndicationHYMPAVZI is indicated for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients 12 years of age and older with:
  • hemophilia A (congenital factor VIII deficiency) without factor VIII inhibitors, or
  • hemophilia B (congenital factor IX deficiency) without factor IX inhibitors.