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About HYMPAVZIAbout
HYMPAVZIOverviewHYMPAVZI in ActionEfficacyEfficacyStudy DesignPrimary EndpointsSecondary EndpointsSafetyDosing & AdminDosing 

& AdminDosingPen OverviewInjection OverviewPatient StoriesPatient
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Full Prescribing InformationPatient InformationInstructions for UseIndication Patient Site
Safety observedSafety observed

BASIS Study Safety

BASIS and OLE Study Safety

Tab Number 3

A majority of adverse reactions were mild to moderate1*BASIS Study N=116. Adverse reactions reported in ≥3% of patients treated with HYMPAVZI1
Adverse Reactions (N=116)Number of Patients, n (%)
Injection site reaction11 (9%)
Headache8 (7%)
Pruritus4 (3%)

*One patient experienced headache that was assessed as severe.2

A serious adverse reaction of peripheral swelling occurred in one patient.1

See PI for guidance on when to discontinue HYMPAVZI.1
See Important Safety Information for a full list of Warnings and Precautions.

 See OLE safety data Loading See OLE safety data Loading

Meet Peter, a real HYMPAVZI patient

Hear Peter's experience using once-weekly HYMPAVZI1

 See Peter’s storyLoadingOLE=open-label extension.The recommended dosage of HYMPAVZI on day 1 is a loading dose of 300 mg (two 150 mg pens) by subcutaneous injection. On day 8 and thereafter, the weekly maintenance dose is 150 mg (one pen) by subcutaneous injection. A dose adjustment to 300 mg subcutaneous injection weekly can be considered in patients weighing ≥50 kg when control of bleeding events is judged to be inadequate by the healthcare provider. Safety and efficacy of HYMPAVZI at doses above 300 mg weekly have not been established.1
OLE Study limitations1,2

The OLE Study is an ongoing observational study in which no formal hypothesis testing was conducted.​ Not all patients in the BASIS Study rolled over into the OLE Study​

  • Enrollment in OLE studies may favorably select patients who are responsive to treatment
  • Results should be interpreted with caution as they may represent chance findings
Adverse reactions reported in ≥3% of patients treated with HYMPAVZI in the BASIS Study and in the ongoing OLE Study (mean follow-up 18 months)1,2
Adverse reactionNumber of Patients n (%)
Injection site reaction17 (15%)
Headache12 (10%)
Pruritus5 (4%)

A serious adverse reaction of venous thrombosis occurred in 0.9% of patients (1/116) treated with HYMPAVZI in the OLE Study. Patients with independent risk factors for thromboembolic events may be at increased risk of thromboembolic events with use of HYMPAVZI.1

Meet Peter, a real HYMPAVZI patient

Hear Peter's experience using once-weekly HYMPAVZI1

 See Peter’s storyLoadingOLE=open-label extension.The recommended dosage of HYMPAVZI on day 1 is a loading dose of 300 mg (two 150 mg pens) by subcutaneous injection. On day 8 and thereafter, the weekly maintenance dose is 150 mg (one pen) by subcutaneous injection. A dose adjustment to 300 mg subcutaneous injection weekly can be considered in patients weighing ≥50 kg when control of bleeding events is judged to be inadequate by the healthcare provider. Safety and efficacy of HYMPAVZI at doses above 300 mg weekly have not been established.1
 References:1. HYMPAVZI. Prescribing Information. Pfizer Inc.; 2025. 2. Data on file. Pfizer Inc.; 2025. 3. Matino D, et al. Blood. 2025. doi:10.1182/blood.2024027468Safety Prefilled pen. Fixed dose.§ Once weekly1

Designed with convenience in mind

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HYMPAVZI is a registered trademark of Pfizer Inc.

To report an adverse event, please call 1-800-438-1985

Pfizer for Professionals 1-800-505-4426

This site is intended only for U.S. healthcare professionals. The products discussed in this site may have different product labeling in different countries. The information provided is for educational purposes only.

© 2026 Pfizer Inc. All rights reserved.

PP-HYM-USA-0601
Indications and usageHYMPAVZI is indicated for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients 12 years of age and older with:
  • hemophilia A (congenital factor VIII deficiency) without factor VIII inhibitors, or
  • hemophilia B (congenital factor IX deficiency) without factor IX inhibitors.
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Important Safety InformationVenous thrombotic events were reported in clinical studies with HYMPAVZI. Patients with independent risk factors for thromboembolic events may be at increased risk of thromboembolic events with use of HYMPAVZI. Consider the benefit and risk of using HYMPAVZI in patients with known risk factors for thromboembolism. Interrupt HYMPAVZI prophylaxis if diagnostic findings consistent with thromboembolism occur and manage as clinically indicated. If factor VIII or factor IX products are indicated in a patient receiving HYMPAVZI prophylaxis, the minimum effective dose of factor VIII or factor IX according to the product label is recommended.

HYMPAVZI may cause hypersensitivity reactions (including, but not limited to, urticaria and pruritus). If HYMPAVZI-treated patients develop a severe hypersensitivity reaction, advise patients to discontinue HYMPAVZI and seek immediate emergency treatment.

Based on its mechanism of action, HYMPAVZI may cause fetal harm when administered to a pregnant woman. Verify that females of reproductive potential are not pregnant prior to initiating HYMPAVZI. Advise pregnant women of the potential risk to the fetus. Advise females of reproductive potential to use effective contraception during treatment with HYMPAVZI and for 2 months after the last dose.

A serious adverse reaction of peripheral swelling occurred in one patient. A serious adverse reaction of venous thrombosis occurred in 0.9% of patients (1/116) in the open-label extension study. Adverse reactions reported in ≥3% of patients treated with HYMPAVZI in clinical trials included injection site reaction (9% of patients); headache (7% of patients); pruritus (3% of patients).IndicationsHYMPAVZI is indicated for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients 12 years of age and older with:
  • hemophilia A (congenital factor VIII deficiency) without factor VIII inhibitors, or
  • hemophilia B (congenital factor IX deficiency) without factor IX inhibitors.