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About HYMPAVZIAbout
HYMPAVZIOverviewHYMPAVZI in ActionEfficacyEfficacyStudy DesignPrimary EndpointsSecondary EndpointsSafetyDosing & AdminDosing 

& AdminDosingPen OverviewInjection OverviewPatient StoriesPatient
StoriesMeet a Real PatientIdentifying Potential PatientsResourcesResourcesResourcesPatient Savings & Support
Full Prescribing InformationPatient InformationInstructions for UseIndication Patient Site
HYMPAVZI injection overviewHYMPAVZI injection overview

Discover how to use the HYMPAVZI prefilled pen.1 See the full Instructions for Use video.

  • Start by inspecting the package and the expiration date
    Make sure there is no damage to the pen and that today’s date is not past the expiration date. Look at the medicine through the window; it should be clear and colorless to light yellow. Do not use if it is cloudy, dark yellow, or contains flakes or particles.
  • Next, choose and clean the injection site
    HYMPAVZI may be injected into the abdomen or thigh (or into the buttocks by a healthcare provider or caregiver). Rotate injection sites each week.
  • Then, twist and pull off the cap
    The needle cover will stay inside the cap after cap removal. It is normal to see a few drops of medicine at the tip of the needle. Do not put hands over the needle guard; doing so may cause injury.
  • To inject, push straight down until there’s a click.
    The click indicates that the injection has started. After the click, continue pushing the pen down firmly against the skin.
  • After the second click, count to 5
    Keeping the pen against the skin, look for a yellow bar to completely fill the window. There will be a second click when the injection is almost complete. Count slowly to 5 after hearing the second click and then remove the pen carefully from the skin.
  • Finished
    Dispose of the entire pen in a sharps container.
  1. Inspect the package and the expiration date
  2. Choose and clean the injection site
  3. Twist and pull off the cap
  4. To inject, push straight down until there’s a click
  5. After the second click, count to 5
  6. Dispose of the entire pen in a sharps container
  • Start by inspecting the package and the expiration date

Make sure there is no damage to the pen and that today’s date is not past the expiration date. Look at the medicine through the window; it should be clear and colorless to light yellow. Do not use if it is cloudy, dark yellow, or contains flakes or particles.

  • Next, choose and clean the injection site

HYMPAVZI may be injected into the abdomen or front of thigh (back of upper arm or into the buttocks by a healthcare provider or caregiver). Rotate injection sites each week.

  • Then, twist and pull off the cap
The needle cover will stay inside the cap after cap removal. It is normal to see a few drops of medicine at the tip of the needle. Do not put hands over the needle guard; doing so may cause injury.
  • To inject, push straight down until there’s a click
The click indicates that the injection has started. After the click, continue pushing the pen down firmly against the skin.
  • After the second click, count to 5
Keeping the pen against the skin, look for a yellow bar to completely fill the window. There will be a second click when the injection is almost complete. Count slowly to 5 after hearing the second click and then remove the pen carefully from the skin.
  • Finished
Dispose of the entire pen in a sharps container.Read the full Instructions for UseLoading

HYMPAVZI is intended for use under the guidance of a healthcare provider. After proper training in subcutaneous injection technique, a patient may self-inject or the patient’s caregiver may administer HYMPAVZI, if a healthcare provider determines that it is appropriate.1​​​​​​​

Meet Peter, a real HYMPAVZI patient

Hear Peter's experience using once-weekly HYMPAVZI1

 See Peter's storyLoadingReference:1. HYMPAVZI. Prescribing Information. Pfizer Inc.; 2025. Dosing & AdminDosing & Admin Resources and support

Download educational resources that can support you and your patients

 See the resourcesLoadingHYMPAVZI is a registered trademark of Pfizer Inc.HYMPAVZI is a registered trademark of Pfizer Inc.

To report an adverse event, please call 1-800-438-1985

Pfizer for Professionals 1-800-505-4426

This site is intended only for U.S. healthcare professionals. The products discussed in this site may have different product labeling in different countries. The information provided is for educational purposes only.

© 2026 Pfizer Inc. All rights reserved.

PP-HYM-USA-0601
Indications and usageHYMPAVZI is indicated for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients 12 years of age and older with:
  • hemophilia A (congenital factor VIII deficiency) without factor VIII inhibitors, or
  • hemophilia B (congenital factor IX deficiency) without factor IX inhibitors.
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Important Safety InformationVenous thrombotic events were reported in clinical studies with HYMPAVZI. Patients with independent risk factors for thromboembolic events may be at increased risk of thromboembolic events with use of HYMPAVZI. Consider the benefit and risk of using HYMPAVZI in patients with known risk factors for thromboembolism. Interrupt HYMPAVZI prophylaxis if diagnostic findings consistent with thromboembolism occur and manage as clinically indicated. If factor VIII or factor IX products are indicated in a patient receiving HYMPAVZI prophylaxis, the minimum effective dose of factor VIII or factor IX according to the product label is recommended.

HYMPAVZI may cause hypersensitivity reactions (including, but not limited to, urticaria and pruritus). If HYMPAVZI-treated patients develop a severe hypersensitivity reaction, advise patients to discontinue HYMPAVZI and seek immediate emergency treatment.

Based on its mechanism of action, HYMPAVZI may cause fetal harm when administered to a pregnant woman. Verify that females of reproductive potential are not pregnant prior to initiating HYMPAVZI. Advise pregnant women of the potential risk to the fetus. Advise females of reproductive potential to use effective contraception during treatment with HYMPAVZI and for 2 months after the last dose.

A serious adverse reaction of peripheral swelling occurred in one patient. A serious adverse reaction of venous thrombosis occurred in 0.9% of patients (1/116) in the open-label extension study. Adverse reactions reported in ≥3% of patients treated with HYMPAVZI in clinical trials included injection site reaction (9% of patients); headache (7% of patients); pruritus (3% of patients).IndicationsHYMPAVZI is indicated for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients 12 years of age and older with:
  • hemophilia A (congenital factor VIII deficiency) without factor VIII inhibitors, or
  • hemophilia B (congenital factor IX deficiency) without factor IX inhibitors.