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About HYMPAVZIAbout
HYMPAVZIOverviewHYMPAVZI in ActionEfficacyEfficacyStudy DesignPrimary EndpointsSecondary EndpointsSafetyDosing & AdminDosing 

& AdminDosingPen OverviewInjection OverviewPatient ProfilesPatient
ProfilesIdentifying PatientsUnmet NeedsResourcesResourcesResourcesPatient Savings & Support
Full Prescribing InformationPatient InformationInstructions for UseIndication Patient Site
Meet the HYMPAVZI pen,
designed for ease of useMeet the HYMPAVZI pen, designed for ease of use

This may be the first pen your patients have ever used, so it’s important they become familiar with all of its parts.

This may be the first pen your patients have ever used, so it’s important they become familiar with all of its parts.

Not actual size.

 CapCap

Remove for injection1

 Needle guard

The needle guard keeps the 27-gauge, pre-attached needle hidden1

 WindowWindow

A yellow bar will appear after use, so patients know they received their complete dose1

 Fixed doseDose strength

150 mg per pen, minimizing the possibility of a dosage error1

 Fixed doseExpiration date

Do not use if the expiration date has passed1

Cap
Remove for injection1
Needle guard
The needle guard keeps the 27-gauge, pre-attached needle hidden1
Window
A yellow bar will appear after use, so patients know they received their complete dose1
Dose strength
150 mg per pen, minimizing the possibility of a dosage error1
Expiration date
Do not use if the expiration date has passed1

HYMPAVZI is intended for use under the guidance of a healthcare provider. After proper training in subcutaneous injection technique, a patient may self-inject, or the patient’s caregiver may administer HYMPAVZI, if a healthcare provider determines that it is appropriate.1

A dose adjustment to 300 mg subcutaneous injection weekly can be considered in patients weighing ≥50 kg when control of bleeding events is judged to be inadequate by the healthcare provider. Safety and efficacy of HYMPAVZI at doses above 300 mg weekly have not been established.1
HYMPAVZI injection overview
LoadingHYMPAVZI injection overviewLoadingReference:1. HYMPAVZI. Prescribing Information. Pfizer Inc.; 2024.Dosing & AdminDosing & Admin Who is the appropriate HYMPAVZI patient?

Uncover the unmet needs and lifestyle considerations that may make patients candidates for HYMPAVZI

 See patient profiles LoadingHYMPAVZI is a trademark of Pfizer Inc.HYMPAVZI is a trademark of Pfizer Inc.

To report an adverse event, please call 1-800-438-1985

Pfizer for Professionals 1-800-505-4426

This site is intended only for U.S. healthcare professionals. The products discussed in this site may have different product labeling in different countries. The information provided is for educational purposes only.

© 2025 Pfizer Inc. All rights reserved.

PP-HYM-USA-0073
Indications and usageHYMPAVZI is indicated for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients 12 years of age and older with:
 
  • hemophilia A (congenital factor VIII deficiency) without factor VIII inhibitors, or
  • hemophilia B (congenital factor IX deficiency) without factor IX inhibitors.
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Important Safety InformationHYMPAVZI is a tissue factor pathway inhibitor (TFPI) antagonist and may increase the risk of thromboembolic complications. Interrupt HYMPAVZI prophylaxis if diagnostic findings consistent with thromboembolism occur and manage as clinically indicated. If factor VIII or factor IX products are indicated in a patient receiving HYMPAVZI prophylaxis, the minimum effective dose of factor VIII or factor IX according to the product label is recommended.

HYMPAVZI may cause hypersensitivity reactions (including, but not limited to, urticaria and pruritus). If HYMPAVZI-treated patients develop a severe hypersensitivity reaction, advise patients to discontinue HYMPAVZI and seek immediate emergency treatment.

Based on its mechanism of action, HYMPAVZI may cause fetal harm when administered to a pregnant woman. Verify that females of reproductive potential are not pregnant prior to initiating HYMPAVZI. Advise pregnant women of the potential risk to the fetus. Advise females of reproductive potential to use effective contraception during treatment with HYMPAVZI and for 2 months after the last dose.

A serious adverse reaction of peripheral swelling occurred in one patient. Adverse reactions reported in ≥3% of patients treated with HYMPAVZI in clinical trials included injection site reaction (9% of patients); headache (7% of patients); pruritus (3% of patients).IndicationHYMPAVZI is indicated for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients 12 years of age and older with:
  • hemophilia A (congenital factor VIII deficiency) without factor VIII inhibitors, or
  • hemophilia B (congenital factor IX deficiency) without factor IX inhibitors.